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Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats
(AlphaMed Press Wiley, 2019-04-22)Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting millions of people worldwide. At present, there is no effective cure for PD; treatments are symptomatic and do not halt progression ... -
Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-induced Alzheimer's disease
(Elsevier, 2018-01-05)Recent studies devoted to neuroprotection have focused on the role of the gamma-aminobutyric acid (GABA) system in regulating neuroinflammatory processes which play a key role in the neurodegenerative processes observed ... -
Lunasin-induced behavioural effects in mice: Focus on the dopaminergic system
(Elsevier, 2013)The present study for the first time is devoted to identify central effects of synthetic lunasin, a 43 amino acid peptide. A markedly expressed neuroleptic/cataleptic effect was observed at low (0.1–10 nmol/mouse) centrally ... -
A common promoter variant of the gene encoding cyclooxygenase-1 (PTGS1) is related to decreased incidence ofmyocardial infarction in patients with coronary artery disease
(Elsevier, 2011)Cyclooxigenase (COX)-1, formally known as prostanglandin endoperoxideH synthetase-1,mediates synthesis of prostaglandin H2,which is subsequently converted to various biologically active metabolites including thromboxane ... -
Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients
(Elsevier, 2013)Aims: The present study was undertaken to investigate the relationship between glyoxalase 1 (Glo1) enzyme activity and painful diabetic neuropathy (DN) in patients with diabetes mellitus. Methods: Glo1 activity and ... -
Breath testing as a method for detecting lung cancer
(Taylor&Francis, 2014)Early diagnosis of lung cancer is important due to high mortality in late stages of the disease. An ideal approach for population screening could be the breath analysis, due to its non-invasiveness, simplicity and cheapness. ... -
Carnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in rats
(Elsevier, 2014)The present study investigates the efficacy of mildronate, a carnitine congener, to protect stress and haloperidol-induced impairment of memory in rats and the expression of brain protein biomarkers involved in synaptic ... -
γ1- and γ2-melanocyte stimulating hormones induce central anxiogenic effects and potentiate ethanol withdrawal responses in the elevated plus-maze test in mice
(Elsevier, 2009)Little is known about the endogenous functions of γ1- and γ2-melanocyte stimulating hormones (γ1- and γ2-MSH). Although γ-MSHs bind to melanocortin receptor subtypes 3 and 4, we have previously shown that these peptides ... -
Breath testing as potential colorectal cancer screening tool
(International Union against Cancer, Wiley, 2015) -
Detection of precancerous gastric lesions and gastric cancer through exhaled breath
(British Society of Gastroenterology, 2015) -
Identification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly
(European Society of Endocrinology, 2011) -
A cross-sectional survey of urinary iodine status in Latvia
(Elsevier, 2014)
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