Veterināro preparātu atlieku noteikšana ar masspektrometrijas metodēm
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Author
Bartkevičs, Vadims
Latvijas Universitāte. Ķīmijas fakultāte
Advisor
Ģībietis, Jānis
Date
2004Metadata
Show full item recordAbstract
Analysis of veterinary drugs residues using masspectrometric methods. Bartkevičs V..
supervisors Dr.chem,J.Ģībietis. Dissertation. 65 pages, bibliography 55 citations. In Latvian.
VETERINARY DRUGS. GAS CHROMATOGRAPHY. HIGH PERFORMANCE
LIQUID CHROMATOGRAPHY, MASS SPECTROMETRY. LEVAMIZOLE, STEROID
SUBSTANCES, ANTIBIOTICS, NSAID GROUP COMPOUNDS.
This dissertation is dealing with determination of veterinary drug residues using
masspectrometric methods. Survey of publications dealing with analysis of levamisole, nonsteroid
anti-inflammatory drugs, steroid compounds and sulphonamides was performed.
Masspectrometric methods for determination of residues of 33 different compounds are
elaborated. Mass spectra of veterinary drugs in different ionisation modes (EI, PCI. NCI,
electrospray) are given and possible fragmentation patterns are described. Optimisation of
analytical methods for detection of veterinary drug residues is performed. Account was made
on achieving highest sensitivity level of analysis and possibilities to apply elaborated methods
for determination of wide range of compounds. Main characteristics of GC-MS and LC-MSMS
methods (linearity, reproducibility and recovery) have been checked. Elaborated methods
have been applied for residue testing of Latvian animal origin products. Results show low
level of occurrence of veterinary drug residues.