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dc.contributor.authorNaidoo, S.
dc.contributor.authorThage, L.
dc.contributor.authorYing, Q.
dc.contributor.authorVallie, S.
dc.contributor.authorVaivars, Guntars
dc.date.accessioned2020-08-26T07:09:57Z
dc.date.available2020-08-26T07:09:57Z
dc.date.issued2019
dc.identifier.issn1757-8981
dc.identifier.urihttps://dspace.lu.lv/dspace/handle/7/52458
dc.description.abstractA unique in vivo electrical pulse generator to improve membrane permeability for drugs and simultaneously facilitate self-powered nano devices for nano drug delivery systems (NDDS) was identified. The use of an unsupported biological catalyst component of the power supply was aimed at the NDDS instead of a conventional membrane electrode assembly (MEA). Self-powered carriers of drugs and prodrugs with improved controlled release capability to target areas using substrate available in biological matrices such as glucose in blood is envisaged. The experimental application implemented prototype designed chambers allowing the entry of premixed precursors and low ohm resistance due the absence of diffusion layers and optimised open circuit voltage (OCV). This would also minimise poisoning and rupturing of the proton exchange membrane (PEM). The model uses the isothermal experimental design (37°C) parameter and the glucose is partly oxidised prior to entry and mostly oxidised at the surface of the proton exchange membrane (PEM). The experimental model used a residence time instead of the usual flow rate. The power was notably high for short periods due to the absence of carbon supported diffusion layers. The findings included low levels of glucose and glucose oxidase (GOx) are needed for OCV optimisation.en_US
dc.description.sponsorshipWe wish to acknowledge the financial assistance of the National Research Foundation (NRF) and the Stellenbosch University support staff; Institute of Solid State Physics, University of Latvia as the Center of Excellence has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART²en_US
dc.language.isoengen_US
dc.publisherInstitute of Physics Publishingen_US
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/739508/EU/Centre of Advanced Material Research and Technology Transfer/CAMART²en_US
dc.relation.ispartofseriesIOP Conference Series: Materials Science and Engineering;503 (1), 012026
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES:Physicsen_US
dc.titleOptimization of the enzyme power source for a nano drug delivery system fuelled by glucose in blood plasmaen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.identifier.doi10.1088/1757-899X/503/1/012026


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